• Question: Are macrophages a type of lymphocyte or phagocyte? And what is their role in the immune system response? - Anonymous
  • Answer:

    Hi Anon. Macrophages are phagocytes, but they are differentiated from leukocytes (specifically monocytes)which might be where some confusion arises. As the term “phagocyte” implies, macrophages can phagocytose pathogens/dead cells/debris and present antigens. The classic macrophages are “killers,” but there is another type of macrophage, M2, that is associated with tissue repair, immune suppression, and tumor progression (Tumor-associated macrophages, or TAMs).

    (To all followers, sorry I’ve been so spotty with the updates. My PhD has been quite busy. Hopefully more content will follow after quals)


Beautiful animation of mucosal immunity from Nature Immunology



Neutrophils may be hypolobulated, but possessing very-round lobes, which may look like spectacles, peanuts, or as round, non-lobed nuclei. This is known as the Pelger-Huët Anomaly This can be caused by either congenital factors or as an acquired condition (known as pseudo Pelger-Huët Anomaly). Where the congenital form is not clinically significant, the acquired condition is, because it is a feature of myelodysplastic syndrome, a precursor to acute leukaemia. Both forms of the Pelger-Huët Anomaly have are similar, but in acquired form there are often other anomalies such as neutropenia or hypogranular neutrophils also.

Pelger-Huët Anomaly is not to be confused with left shift, in which there is a higher proportion of less lobulated neutrophils in the blood compared to well-lobulated neutrophils.

(via fyeahmedlab)

Source: haematologytidbits

A lot has been happening lately.  First of all, scientists have functionally cured a child of HIV.  Far less importantly, I have moved across the country, begun an Immunology Ph.D. program, and completed my rotations and chosen a lab!  Posts will slowly be resuming, and feel free to submit or ask for certain topics.



Kupffer cells are specialized macrophages that patrol tiny vessels in the liver called sinusoids, recycling old red blood cells and ingesting pathogens. The endothelium of these vessels is perforated with large holes, allowing the Kupffer cells to migrate into liver tissue at sites of inflammation and damage.

(via fyeahmedlab)

Source: amolecularmatter


Dendritic Cells Activating a Lymphocyte

Here is a beautiful scanning electron micrograph of a human lymphocyte (pink) as it scans the surface of a dendritic cell (blue).

Lymphocytes are white blood cells, of which there are three types: B cells, T cells, and natural killer (NK) cells. Dendritic cells are located in the tissue and are responsible for stimulating the adaptive immune response via the activation of T cells.

(via sfoviayyztomorrowlieswest)

Photo Set


Center for Pediatric Hematology, Oncology and Immunology

The human face of immunology

Source: psphotos

Undergrad Medical Laboratory Student: Humoral Immunity/Antibody-Mediated


In a Humoral Immunity response, the cells do not attack, but create antibodies that will attack.

This involves the B Cells. B Cells are not named “B” because they come from the bone marrow, but because they were originally found in the bura of fabricias in birds. The…

(via medhatter-deactivated20120103)

Source: mama-grizzly

Effyeahimmunology is back, and with a new and fully functioning computer, as well as a shiny new degree.  I’m going to reblog some of the immunology posts that happened over the hiatus while I put together some new posts.  Feel free to let me know if there’s any particular subject that you’d like to see!


My computer is dead.  I’m borrowing a computer right now, but I’ll hopefully have a new one soon.  Also, hello to all of our new followers!